P-17: Modulation of Wnt/?catenin and AktSignaling Activities in Rat Granulosa Cells byUsing Recombinant Secreted Frizzled RelatedProtein Type-4
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منابع مشابه
exogenous secreted frizzled-related protein-4 modulates steroidogenesis of rat granulosa cells through wnt/bcatenin and pi3k/akt signaling pathways
background: it has been reported that secreted frizzled-related protein-4 known as an antagonist of wnt signaling pathway plays a role in luteinization process of rodent granulosa cells. the purpose of this study was twofold: 1) to determine whether recombinant human secreted frizzled-related protein-4 (rhsfrp-4) could directly induce terminal differentiation of rat granulosa cells (gcs) and 2)...
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Background: Involvement of Wnt proteins and one of its antagonist known as secreted Frizzled Related Protein type-4 (sFPRP-4) was reported in rodent ovarian follicular development. Other studies showed an ap- Abstracts of the 11th Royan International Congress on Reproductive Biomedicine 7 7 International Journal of Fertility & Sterility (IJFS), Vol 4, Suppl 1, Summer 2010 optotic-associated exp...
متن کاملimmunohistochemical analysis and role of secreted frizzled-related protein-4 in polycystic ovary-induced rat
objective: the role of wnt signaling and its antagonist; secreted frizzled related protein type 4 (sfpr4) was reported in rodent ovarian follicular development. this study examines immunolocalization of sfrp4 in ovaries of polycystic ovary (pco) rat model and evaluates its role in follicular growth arrest and its premature differentiation. materials and mathods: pco was induced with daily admin...
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BACKGROUND It has been reported that secreted frizzled-related protein-4 known as an antagonist of Wnt signaling pathway plays a role in luteinization process of rodent granulosa cells. The purpose of this study was twofold: 1) to determine whether recombinant human secreted frizzled-related protein-4 (rhSFRP-4) could directly induce terminal differentiation of rat Granulosa Cells (GCs) and 2) ...
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background: gap-junctional intercellular communication (gjic) is implicated in physicological processes and it is vitally important for granulosa cell (gc) differentiation and oocyte growth. we investigated the expression of connexin 43 (cx43), a gap junctional protein, in normal and androstenedione-induced polycystic ovary (pco), the effects of androstenedione on cx43 expression, gjic and prog...
متن کاملSecreted frizzled-related protein 4 reduces insulin secretion and is overexpressed in type 2 diabetes.
A plethora of candidate genes have been identified for complex polygenic disorders, but the underlying disease mechanisms remain largely unknown. We explored the pathophysiology of type 2 diabetes (T2D) by analyzing global gene expression in human pancreatic islets. A group of coexpressed genes (module), enriched for interleukin-1-related genes, was associated with T2D and reduced insulin secre...
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عنوان ژورنال
دوره 4 شماره 2
صفحات -
تاریخ انتشار 2010-05-01
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